Abstract: Internationally, two advanced nondestructive methods of drill core testing include hyperspectral technology and XRF scanning technology. Both methods include problems that the higher the accuracy requirements, the higher the accuracy of the complete core data, the less accurate data of the incomplete core and rock specimen, and the difficulty of satisfying fast and accurate requirements of small sampling areas of the geological samples. Portable X-ray Fluorescence Spectrometry (P-XRF) was used for the study described in this paper. The weighted average of the multi-point test method reduces the influence of complex sample lithology and mineral species and improves the accuracy of this method. Compared with quantitative analysis, the results with a semi-quantitative range indicator role are more than 82%. The weighted average is nearly 22% higher than the arithmetic mean, and thus the accuracy of the multi-point test is improved significantly. Furthermore, the method can be used to analyze more elements after the rough processing of specimens, which better solves the sampling problem of specimens in the geological cores and samples library. Through this pre-research, it is found that silver content is higher in some specimens of lead-zinc mine and Mo content is 0.3% in the 168.46-171.24 m position of drilling core Zk0901. This study provides important prospecting information for the reuse of the specimens in the geological cores and samples library.