Abstract: A method for the determination of phenol compounds in ground surface water samples by high performance liquid chromatography (HPLC) was developed. The phenol compounds including phenol, paranitrophenol, metacresol, 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol are extracted with GDX-502 resin as solid phase extraction column and eluted with acetonitrile and then determined by HPLC with doublewavelength (at wavelength of 280 nm and 290 nm) ultraviolet detector. The results show that the detection limit of the method is 0.01～0.05 mg/L for these phenol compounds, the average recovery for 1 L water samples is 82.5%～95.0% with precision of 3.6%~9.2%RSD (n=7). The method has been applied to the determination of trace phenol compounds in practical ground surface water samples with the advantages of simplicity, less organic solvent consumption, high efficiency and low cost.