国家地质实验测试中心, 北京 100037
中国地质调查局自然资源综合调查指挥中心, 北京 100055
中国农业大学理学院, 北京 100193
Excretion Rate and Accumulating Rate of p, p'-DDE in Beijing Resident during Consecutive Lactation
National Research Center for Geoanalysis, Beijing 100037, China
Command Center of Natural Resources Comprehensive Survey, China Geological Survey, Beijing 100055, China
College of Science, China Agricultural University, Beijing 100193, China
摘要：母乳中p，p’-DDE浓度是监测母体短期内p，p’-DDE的“静态”蓄积水平，估算婴幼儿每日摄入量的重要技术手段。本文旨在通过监测北京女性两个相邻哺乳期内母乳中p，p’-DDE浓度及变化，估算两次分娩间隔期母体内p，p’-DDE的“动态”富集速度，并根据每日摄入量掌握人体p，p’-DDE的长期变化趋势。在2009年至2019年期间，收集了43名女性首次分娩后六个月内和18名女性第二次分娩后六个月内的母乳样本，并采用气相色谱法检测了母乳中p，p’-DDE的浓度。实验结果表明，母乳中p，p’-DDE浓度在哺乳期持续下降。年龄和分娩次数是母乳中p，p’-DDE浓度的影响因素，p，p’-DDE浓度随母亲年龄增大而升高，随分娩次数增多而降低。18名母亲两个哺乳期内母乳中p，p’-DDE平均排泄速度计算结果表明，排泄速度从18.9μg/kg lipid/month降低到16.8μg/kg lipids/month。而母体两次分娩隔期内p，p’-DDE年富集速度估算值为正，分布在10.9~14.9μg/kg lipids/year之间，每日摄入量分布在29.8~40.8ng/day/kg.b.w.之间。因此北京女性哺乳期母体内p，p’-DDE月排泄速度与母体年富集速度数值相当，母体p，p’-DDE每日摄入量远低于世界卫生组织（WHO）建议值，北京女性是低风险暴露人群。
Excretion Rate and Accumulating Rate of p, p'-DDE in Beijing Resident during Consecutive Lactation
Monitoring of p, p'-DDE in breast milk was a significant way to evaluate the p, p'-DDE accumulation level in human beings within a short-term and calculate daily intake for infants. Although the investigation of classic organic chlorine pesticides in Beijing breast milk showed that p, p'-DDE was detected with the highest residue level. The study on the accumulating rate of p, p'-DDE, indicated a dynamic and long-term change, in Beijing females this was neglected and scarce.
To detect p, p'-DDE in breast milks from two consecutive lactations, estimate the excreted speed during each lactation along with the impact of delivery times on residue level of p, p'-DDE in mothers, and estimate its annual accumulating rate in Beijing residents.
During 2009-2019, breast milk samples were collected from 43 mothers during their first lactation and 18 of them during their two consecutive lactations. The concentration of p, p'-DDE in breast milk was determined by gas chromatography.
The analytical results showed that the p, p'-DDE in breast milk decreased continuously during each lactation. Age and the number of childbirths were the influencing factors of the concentration of p, p'-DDE in breast milk. The concentration of p, p'-DDE increased with the age of mothers and decreased with the number of childbirths. In addition, the average excretion speed of p, p'-DDE in breast milk from 18 twice-birth mothers decreased from 18.9μg/kg lipids per month within the first lactation to 16.8μg/kg lipids per month within the second lactation. The estimated value of the annual enrichment rate of p, p'-DDE in the interval between two births of the mother was positive, from 10.9μg/kg lipids per year to 14.9μg/kg lipid per year during the consecutive deliveries. Daily intake of p, p'-DDE was from 29.8ng/day/kg.b.w. to 40.8ng/day/kg.b.w..
The depurated dose of p, p'-DDE in mothers within a month of lactation was equal to the accumulating dose in a year. The estimated daily intake of p, p'-DDE was far lower than the suggested value of WHO. The Beijing female was in a low exposure risk environment.
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