【引用本文】 马健生, 王卓, 张泽宇, 等. 哈尔滨市地下水中29种抗生素分布特征研究[J]. 岩矿测试, 2021, 40(6): 944-953. doi: 10.15898/j.cnki.11-2131/td.202101040001
MA Jian-sheng, WANG Zhuo, ZHANG Ze-yu, et al. Distribution Characteristics of 29 Antibiotics in Groundwater in Harbin[J]. Rock and Mineral Analysis, 2021, 40(6): 944-953. doi: 10.15898/j.cnki.11-2131/td.202101040001


中国地质调查局沈阳地质调查中心, 辽宁 沈阳 110032

收稿日期: 2021-01-04  修回日期: 2021-05-26  接受日期: 2021-07-28

基金项目: 中国地质调查局地质调查项目"松嫩平原水文地质调查"(DD20190340)

作者简介: 马健生, 硕士, 高级工程师, 主要从事有机地球化学研究。E-mail: mjs1015@163.com

通信作者: 李丽君, 硕士, 高级工程师, 主要从事有机地球化学研究。E-mail: 475876904@qq.com

Distribution Characteristics of 29 Antibiotics in Groundwater in Harbin

Shenyang Centre of Geological Survey, China Geological Survey, Shenyang 110032, China

Corresponding author: LI Li-jun, 475876904@qq.com

Received Date: 2021-01-04
Revised Date: 2021-05-26
Accepted Date: 2021-07-28


关键词: 地下水, 抗生素, 喹诺酮, 空间分布, 超高效液相色谱-三重四极杆串联质谱法


(1) 通过对哈尔滨市地下水采集与测试探究该地区典型抗生素的含量及分布。

(2) 地下水典型抗生素主要检出区域集中在城市中南部及东部人口密集地区。

(3) 制药厂、畜牧业、城市污水排放对地下水中抗生素分布特征有显著影响。

Distribution Characteristics of 29 Antibiotics in Groundwater in Harbin



At present, the supervision of antibiotic abuse and its research is being strengthened. In recent years, antibiotics have been detected in varying degrees in water in central China. This reinforces the concern of the pollution of antibiotics in surface and groundwater.


To investigate the distribution characteristics of 29 antibiotics in groundwater in Harbin.


A total of 26 groups of groundwater samples were collected in Harbin, and the sampling scope included habitation and production areas such as densely populated, industrial production, agricultural districts and animal husbandry. The ultra-performance liquid chromatography-triple quadrupole mass spectrometry method was used to analyze 29 kinds of antibiotics covering six types, including sulfonamides, quinolones, macrolides, β-lactams, tetracyclines, and lincosamides.


Antibiotics in the groundwater of Harbin were mainly composed of sulfonamides, quinolones, macrolides and tetracyclines and the detection rates were 61.5%, 46.2%, 42.3% and 38.5%, respectively. The content of antibiotics detected ranged from 0.02 to 681ng/L, and the highest contents of sulfathiazole, sulfadiazine, and lincomycin were more than 100ng/L. The average content of quinolones was low compared with some domestic and international areas (such as Beijing, Tianjin, and Barcelona). Sampling sites with higher antibiotic levels were mainly found in the central, southern and eastern regions of the city. These areas are also relatively densely populated and are generally distributed around pharmaceutical factories, urban sewage outlets, and poultry and livestock farms.


The distribution characteristics of antibiotics in groundwater in Harbin are strongly related to the impact of human production and living activities.

KEY WORDS: groundwater, antibiotics, quinolones, space distribution, ultra performance liquid chromatography-triple quadrupole mass spectrometry


(1) The content and distribution of typical antibiotics were explored by the collection and testing of groundwater in Harbin.

(2) Typical antibiotics were detected mainly in densely populated areas in the south central and eastern parts of the city in groundwater.

(3) The discharge of pharmaceutical factories, animal husbandry and urban sewage has a significant impact on the distribution of antibiotics in groundwater.



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马健生, 王卓, 张泽宇, 刘强, 李丽君